CSF markers and MRI lesion volume as relapse predictors for dogs with MUO

In this live webinar, Drs. Spohn and Nessler explore their recent paper on utilizing CSF and MRI to predict the likelihood of relapse in dogs with meningoencephalitis of unknown origin (MUO). Repeated MRI exams are advantageous for monitoring dogs with MUO. A recent study suggested a follow-up MRI three months post-diagnosis, along with CSF analysis, to evaluate treatment success. Nonetheless, image interpretation remains subjective. To tackle this, recent research has investigated quantitative methods, such as measuring total lesion burden and assessing brain atrophy based on the level of interthalamic adhesion relative to brain volume, which may affect prognosis. This study aimed to analyze MRI, CSF, and clinical findings in dogs with MUO undergoing immunosuppressive therapy, and to identify potential predictors of relapse. The research focused on longitudinal changes in lesion volume, the appearance of new lesions, CSF markers, and their connection to neurological status and treatment decisions.